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This recognition encouraged preclinical studies aiming to investigate both mechanistic aspects and intervention strategies to characterize and target this biological axis in conditions affecting muscle, brain, the immune system, and metabolic diseases

It is fair to say that methylation is almost synonymous with physical function

Clinical trials reported positive results in a wide range of applications, including Parkinsons disease [35], bronchiectasis [36], metabolic dysfunction-associated steatotic liver disease [37], exercise-induced fatigue [38,39], lead exposure [40], and healthy aging [41,42]

Antioxidants, 9(4), 303