Pain 138:318329 Al-Khrasani M, Lack E, Riba P, Kirly K, Sobor M, Timr J, Mousa S, Schfer M et al (2012) The central versus peripheral antinociceptive effects of -opioid receptor agonists in the new model of rat visceral pain
Inositol tends to make the most sense when the goal is supporting insulin signaling and related reproductive function over time not when someone is expecting a fast, guaranteed, or dramatic change
For patients with a history of treated and stable malignancies, tesamorelin therapy should be initiated only after careful evaluation of the potential benefit of treatment relative to the risk of re-activation of the underlying malignancy
Future clinical studies should account for baseline choline status, microbiome profiles, genetic polymorphism in choline metabolic pathways, and organ-specific outcomes to define optimal strategies for leveraging the use of modulating choline availability and metabolism in personalized therapeutic interventions