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Besides vaginal birth and being heavily overweight, one of the causes for POP is diminished vaginal tissue stiffness through the reduction of collagen with age and hormonal changes 128,129

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Additionally, nanocarriers designed for site-specific release can reduce the required dosage and mitigate potential cytotoxic effects

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Note: The lower initial dose (2.5 mg weekly) is intended to reduce GI symptoms

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Simultaneously, by stimulating the GLP-1 receptor, the medication reduces appetite and food intake , leading to weight loss

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