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Wegovy has a safety advantage for people without gallbladders compared to some alternatives

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Discontinuation due to factors typically irrelevant in clinical trial settings (i.e., cost or insurance-related issues and medication shortages) could contribute to the substantial discrepancy between discontinuation rates in pivotal phase 3 trials and those reported in real-world studies. Regarding discontinuation due to side effects, Gasoyan says we do not currently know of patient-level predictors that would help identify who might experience side effects and why

Whilst these drugs offer significant metabolic benefits, understanding their potential impact on skeletal health is essential for comprehensive patient care