Its necessary for brain function, muscle contractions, and turning body fat into usable energy (i.e., improving fat-burning)
In these cases, their doctor may choose to prescribe a compounded medication. Facilities that offer compounded drugs must follow state and federal regulations, which, among other things, require compounded drugs to be administered by a licensed healthcare provider and prohibit compounders from deceiving patients into believing products are FDA-approved or proven to achieve certain results
In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )
however, it requires hepatic transformation to its active metabolite via CYP2D6, resulting in unpredictable pharmacokinetics in patients with liver disease