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GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have transformed type 2 diabetes and weight management
RAGE engagement triggers NFkB, leading to generation of reactive oxygen species with mitochondrial dysfunction in both podocytes and endothelial cells, fostering inflammation and fibrosis
Danuglipron and lotiglipron both fell to liver signals, and Pfizer's experience has made the FDA and other agencies acutely sensitive to transaminase data in oral GLP-1 programs
pmid:10386436 20
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