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The residue A263 from the I domain, situated at the buried interface and close to the specificity-determining loop (SDL) of the molecule, makes a strong H-bond between its backbone carbonyl oxygen and the 25-OH group of 25HC

However, results vary considerably across different populations and conditions

7gi) as observed for Pt GSTF8, suggesting that the proposed catalytic mechanism and active site architecture are conserved between arGSTs from different plant origins

Glutathione given intravenously offers higher bioavailability than most oral preparations, because it bypasses the digestive tract, where the tripeptide is largely broken down