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Creatine causes intracellular water retention in muscle tissue, leading to initial weight gain of 2-4 pounds that may mask fat loss from tirzepatide on the scale

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Common side effects The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn