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Selenium status becomes rate-limiting: targeting plasma selenium of 120150 g/L through selenomethionine 200 g/day is more effective in these carriers than in wild-type individuals

In summary, the reprogramming of hepatocytes associated with a profibrotic milieu results in loss of mature parenchymal cells, characterized by loss of the master hepatocyte transcription factor HNF4 (158, 212) and upregulation of the developmental Notch, Hippo (213), and Hedgehog (214) signaling pathways