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Finally, the increase of GSH is related to the drug resistance of tumor cells

A naturally occurring antioxidant ALA helps protect your cells from damage caused by free radicals unstable molecules linked to inflammation, aging, and chronic disease.10 Most antioxidants work in either water (like vitamin C) or fat (like vitamin E), but ALA is both water- and fat-soluble.9 That dual solubility allows it to protect a wider range of tissues throughout the body

NNMT (nicotinamide N-methyltransferase) catalyses transfer of a methyl group from S-adenosylmethionine to nicotinamide

Femiano F., Gombos F., Scully C., Busciolano M., Luca P