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doi: 10.1210/endo.143.5.8850 46 PotthoffMJBoney-MontoyaJChoiMHeTSunnyNESatapatiSet al

Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

Overall, the addition of oral semaglutide 7 mg or 14 mg compared favorably to the addition of sitagliptin 100 mg in patients with T2DM inadequately controlled on metformin sulfonylurea background therapy

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