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doi:10.1097/MCO.0000000000000134 Vzquez-Meza H, Vilchis-Landeros MM, Vzquez-Carrada M, Uribe-Ramrez D, Matuz-Mares D
Adequate intracellular levels of glutathione are required for the proper proliferation and activity of lymphocytes (T-cells and B-cells) and natural killer (NK) cells
This novel feature of TNBS to wear off GSH, coupled with its potential for ROS generation, demonstrates that TNBS promotes two independent mechanisms of injury, namely, GSH limitation and ROS accumulation, which in cooperation trigger a chain of processes that lead to cell damage
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