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(1) S J Getting, H B Schith, and M Perretti (2003) Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides Journal of Pharmacology & Experimental Therapeutics, 2003 Aug, Volume 306 (Issue 2), Pages 631-7
Thus, although some of the damage in this experimental model of colitis reflects a direct erosive effect of TNBS and ethanol, their combined administration to rats reflects the in vivo operation of the damaging mechanisms elicited by TNBS, namely GSH depletion and ROS generation, indicating that ethanol facilitates the access of TNBS to the cell interior ensuring TNBS-induced GSH depletion and ROS generation
Options include adjusting dose timing, changing the dosage, or considering alternatives like sertraline (generic Zoloft)
This suggests an association between local oral events and bile acid concentration (Yang et al., 2023)
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