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The molecule has to penetrate the stratum corneum (the skin's outer barrier) to reach the dermis where collagen is actually produced

The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A

TGF- can downregulate inflammatory processes by promoting Treg expansion and inhibiting effector T-cell function, as well as drive collagen deposition by fibroblasts as part of the normal wound repair process (90, 91)

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