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Preclinical models: Humanized GA models incorporating dietary/metabolic stressors are needed to recapitulate FA-immune interactions (241)

Baseline Demographics and Medication Profiles A total of 125 youth were included (median age 14.83 years), with 113 on metformin and 12 on GLP-1RA therapy

50% of patients find relief from gastrointestinal symptoms by adjusting their diet, confirming that diet changes are not guesswork but a high-yield first step

Trimi's compounded semaglutide uses the same active pharmaceutical ingredient but is prepared per individual prescription by a 503A compounding pharmacy and isn't reviewed by the FDA for safety, effectiveness, or quality before marketing