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Already in the 1940s, Charles Huggins and his colleagues demonstrated the effectiveness of ADT through surgical castration, which removes the major source of systemic androgen synthesis, as a treatment for advanced metastatic CaP [5, 6]
It neutralizes free radicals, reduces oxidative stress at the cellular level, and inhibits tyrosinase, the enzyme that drives melanin production
[19] Ate K, Salaba E, zmez A, et al
SGLT2 Inhibitor and GLP-1 receptor agonist combination therapy substantially improved the renal function in a patient with type 2 diabetes: implications for additive renoprotective effects of the two drug classes
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