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Why Vitamin B12 Deficiency Is a Concern With GLP-1 Medicines Reduced appetite from GLP-1-based medicines can lower intake of animal-derived B12 sources

After seven days, roughly 38% of the previous dose remains, compared to about 50% for semaglutide

No identified clinically significant effect of anti-semaglutide antibodies on pharmacokinetics of RYBELSUS was observed

Results at 68 weeks: 40.4% of CagriSema participants lost 25% or more of their body weight 91.9% lost at least 5% Blood pressure fell by 10.9 mmHg systolic on average About 40% of participants reduced or stopped blood pressure medications 87.7% of those with prediabetes at baseline achieved normal blood sugar Results were published in the New England Journal of Medicine and presented at the American Diabetes Associations 2026 Scientific Sessions