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The mRNA expression of TGF-1 , a known anti-inflammatory factor, was significantly increased by dietary L-carnitine supplementation in the muscle in the feeding and fasting states
However, the application of CeO x -based nanozyme to suppress ROS levels still faces the major challenge that Ce (III) would rapidly react with ROS to oxidize Ce (IV) in the pathological microenvironment, disrupting the original redox cycle to restrict its catalytic activity, so that it is essential to introduce an extra stabilizer to maintain the nanozyme function 18
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Note that this level was somewhat arbitrary, and was chosen so that only children with significant toxic metal excretion would enter phase two
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