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(54) found that administering GIPR antagonist to healthy humans reduced postprandial insulin secretion and increased glucose excursions more than administering GLP-1R antagonist (GLP-1RA), indicating that endogenous GIP may play a more significant role in stimulating insulin secretion and reducing postprandial plasma glucose excursions compared to endogenous GLP-1

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Unlike signaling pathways restricted to cytosolic proteins, the lipid bilayer forms a continuous, laterally diffusive structure in which oxidized lipids and radical intermediates can, at least in principle, spread within and between membrane microdomains