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Therefore, we found that the enhanced insulinotropic effect of exendin-phe1 in vitro is recapitulated in a mouse model of T2D, suggesting that GLP-1R trafficking plays a role in determining the responses to therapeutic GLP-1R agonists in vivo

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With liraglutide treatment, we did not find an increased expression of mRNAs of inflammatory cytokines (TNF- and IL-1 ) or chemokines (MCP-1 and CX3CL1) in activated PSCs

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