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Studies were conducted with permission from the Danish Animal Experiments Inspectorate (2023-15-0201-01408) and the local ethical committee (EMED P23-262 and P23-263) in accordance with the EU Directive 2010/63/EU and guidelines of Danish legislation governing animal experimentation (1987) and the National Institute of Health
[24] [25] According to a study published in 2019, disruption of mitochondrial homeostasis caused by NAD+ depletion is a significant contributor to the metabolic dysfunction in WS
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