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Therefore, because neurotransmitter imbalance contributes to depressive behaviors in patients with depression as described above, the appropriate modulation of neurotransmitters in the brain is key to treating depression ( Figure 2 )
Age is a key factor
The side effect profile is more serious than GLP1R agonists , including depression and suicidal ideation and it is not approved for other types of obesity
Without this repulsion, molecules collide, stick together, and form aggregates that can range from soluble oligomers (still somewhat active but less potent) to insoluble particles (completely inactive)
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