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Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award numbers R41CA240124, R42CA240124, R37CA065910, and P30CA023074

Metabolic dysfunction associated with steatotic liver disease associated with alcohol consumption of 140350 g/week in women and 210420 g/week in men was defined

Furthermore, participants assigned to tirzepatide had a slower mean rate of decline in estimated glomerular filtration rate over the study period: 1.4 0.2 ml/min/1.73 m 2 body mass per year with tirzepatide compared with 3.6 0.2 ml/min/1.73 m 2 body mass per year with insulin glargine, for a between-group difference of 2.2 ml/min/1.73 m 2 body mass per year [95% CI 1.62.8 ml/min/1.73 m 2 body mass per year] [95]