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Two meta-analyses suggested that pioglitazone reverses or delays the progression of fibrosis, including advanced-stage fibrosis, which is an independent predictor of liver-related adverse events and mortality in MASLD/MASH patients

Although the prescription drug is FDA approved for diabetes, it is being prescribed off-label for weight loss, necessitating careful monitoring of health risks such as high blood pressure, high cholesterol, sleep apnea, and problems digesting food

In addition to these improvements in metabolic disorders, GLP-1 signaling also plays an important role in suppressing inflammation

Types of lumbar herniated disc and clinical course