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doi: 10.1016/j.trecan.2022.12.008 137 IwakiriDZhouLSamantaMMatsumotoMEbiharaTSeyaTet al

Necrotic inflammation associated with ferroptosis has been observed in the kidneys in an AKI model induced by crystal (oxalate) and folic acid and in a GPX4 deletion mouse model 88

In people with obesity, particularly in cases of rapid or marked weight reduction, the decline in lean mass may account up to 2530% of the total weight loss, contributing to the so-called sarcopenic obesity [18]

Currently, retatrutide exists only as a research chemical in the US, sold under research-use-only labeling for laboratory and animal study