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Similarly, resistance to oxidative attack increased after overexpression of GPX5 in CHO-K1 cells, and GPX5 overexpressing cells reduced lipid peroxidation levels and downstream DNA damage marker 8-OXODG levels compared to control cells (Taylor et al., 2013)

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A chronically altered thalamic microenvironment whether reflecting subtle neuronal, glial, or microvascular changes could plausibly be associated with a shifted oxidative / antioxidant balance that is detectable as lower GSH

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