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doi:10.1073/pnas.79.2.345
Deficiency of BMPR2, a core mediator of NK cell homeostasis, can lead to NK cell dysfunction by impairing IL-15 signaling, which is involved in the pathogenesis of PH (Figure 1, involves multi-dimensional mechanisms such as metabolic reprogramming, inflammasomes, complement pathways, and intercellular signal crosstalk, providing a rich theoretical basis for the development of immune-targeted therapeutic strategies for PH
