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Increased endocannabinoids inhibit monoacylglycerol lipase (Alhouayek et al., 2011), thereby reducing systemic inflammation, altering intestinal peptide secretion and increasing intestinal mucosal barrier thickness

Efficacy also showed a modest reduction with age: each additional 10 years of age corresponded to a 0.5% reduction in BMI change (around 0.45 kg reduced weight loss efficacy), which is directionally consistent with recent clinical trial meta-analyses 12,13

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