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Dysesthesia occurred in 5.1% (4 mg), 12.3% (9 mg), and 12.5% (12 mg) of patients treated with retatrutide, compared to 0.9% with placebo, although this was generally mild to moderate and resolved during treatment

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Staying hydrated, eating smaller frequent meals, and avoiding high-fat foods during early weeks minimizes gastrointestinal upset

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If you are working with a 10 mg vial reconstituted to a known concentration, calculating half-doses requires careful math

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