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Stage III melanosomes are fully functional organelles that exhibit active melanogenesis, during which the synthesized melanin is progressively deposited onto fibrils [7]

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While gut microbiota modulation of drug efficacy against CVD is harnessed, its combination with physical exercise will lead to healthier cardiovascular organ functions ( 4 Gut microbiota-mediated therapeutic strategies for cardiovascular disease To prevent CVD, current strategies include evidence-based approaches such as dietary and lifestyle modifications, pharmacological interventions, as well as novel approaches like fecal microbiota transplantation (FMT) and NLRP3 inflammasome inhibition