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10.1080/17435889.2025.2457315 176 WangH.ZhangH.SunL.GuoW

Histone deacetylase (HDAC) inhibitors, such as vorinostat (SAHA), induce high acetylation of DMT1, enhancing its membrane localization and Fe influx, thereby sensitizing tumor cells to ferroptosis and increasing their sensitivity to chemotherapeutic drugs[221]

Among the supplemental NAD+ precursors available, its nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) that stand out for their combination of efficacy and relatively small side effect profiles