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From a mechanistic perspective, GLP-1RAs like exenatide notably decreased the percentage of Th17 cells while promoting the proliferation of Tregs by influencing the signaling cascade encompassing phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), along with forkhead box O1 (FoxO1) [147]
IL-1 was obtained from PeproTech (Neuilly-sur-Seine, France)
doi:10.1007/s11892-022-01477-w 16
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