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Common (affecting one in 10100 people): Decreased appetite, vomiting, constipation, abdominal pain, dyspepsia, abdominal distention, eructation, flatulence, gastro-oesophageal reflux disease, hypoglycaemia when used with metformin plus an SGLT2 inhibitor, increased heart rate, increased lipase, increased amylase, hypersensitivity reactions, fatigue and injection site reactions

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This suggests that Retatrutide might help people lose more weight compared to other weight-loss drugs, like Zepbound