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Complementary modeling studies suggest that GLP-1 RAs such as semaglutide and tirzepatide may disrupt the typical feedback loop in which weight loss leads to compensatory increases in appetite, potentially extending the period of reduction before plateauing occurs
It has not been approved by the U.S
Semaglutide is highly protein-bound and metabolised through proteolytic degradation at a rate determined by your individual physiology, which cannot be meaningfully altered by hydration
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