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Are the anti-inflammatory effects of GLP-1 drugs direct or indirect
Recent systematic reviews and meta-analyses on GLP-1RA and mental health outcomes have also shown that the subjects included in the trials, such as obese individuals, patients with type 2 diabetes, and subgroups with mental disorders, have significantly increased baseline depression and suicide risks themselves [29, 46, 47]
10.6061/clinics/2020/e1708 25
Simultaneously, it downregulates genes associated with inflammation (IL-6, TNF-alpha), oxidative damage, fibrosis (TGF-beta in some contexts), and tissue destruction (certain metalloproteinases)
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