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3 GLP-1 receptor signaling and GLP-1RA in metabolic disorders The global prevalence of metabolic dysfunction, encompassing obesity and T2DM, has reached pandemic proportions (Chew et al., 2023), characterized by a complex interplay of insulin resistance (Barber et al., 2021), low-grade systemic inflammation (Rohm et al., 2022), and organelle dysfunction (Arruda and Hotamisligil, 2015
23(2): 906 Savica V, Bellinghieri G, Di Stefano C, et al
Inflammation and immune function
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