Vitamin B12 deficiency is typically accompanied by fatigue, weakness, loss of appetite, and constipation
Its impact on monoamine neurotransmitters offers unique insights into hunger, satiety, and potentially even food reward pathways
Intrinsic factor deficiency, or "congenital pernicious anemia," is a rare autosomal recessive disorder characterized by the lack of gastric intrinsic factor in the presence of normal gastric acid secretion and mucosal cytology (ie, without gastritis) and in the absence of intrinsic factor antibodies found in the acquired form of pernicious anemia
The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )