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The authors reported three distinct states for DNA-bound AR, which they named entrenched, splayed and divorced architectures, and which reflect conformations with increasing distance between the two AR monomers

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Practical precautions for all patients include: Maintaining adequate hydration as part of overall health Staying physically active and avoiding prolonged immobility Continuing prescribed anticoagulation if already indicated for other conditions Discussing travel plans, as long flights or car trips may require movement strategies Reporting any new medications or supplements to healthcare providers For patients undergoing elective surgery while taking semaglutide, discussion with both the prescribing physician and surgeon is important regarding perioperative management