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At this level, the central nervous system is severely suppressed, and vital functions like breathing and heart rate slow to life-threatening levels

Insulin resistance is also commonly observed in women with lipedema, particularly in those with higher body weight or coexisting metabolic conditions (Patton et al., 2025)

Furthermore, many included studies used either preceding or concurrent treatment to manage dumping syndrome so these outcomes cannot be completely attributed to the GLP-1 RM alone

Branched-chain amino acid aminotransferase 2 (BCAT2), a key enzyme engaging in the metabolism of sulfur amino acids, can regulate the intracellular level of glutamate, which can maintain the function of system Xc and protect cancer cells from ferroptosis [86]