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Briefly, neurovascular coupling describes the change in cerebral oxygen extraction or blood flow delivery to meet the metabolic demands of active neurons (Phillips et al., 2016)

A typical four-week titration schedule for cognitive research models follows this pattern: Week 1 : 0.5mg/kg three times weekly (Monday/Wednesday/Friday) Week 2 : 1.0mg/kg three times weekly Week 3 : 1.5mg/kg three times weekly Week 4 : 2.0mg/kg three times weekly The three-day dosing interval (every 4872 hours) accounts for Dihexa's estimated half-life of 24 hours in rodent models, allowing complete clearance between doses while maintaining cumulative exposure over the study period

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Can KPV be used topically