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As described above, cAMP, CRE-binding proteins, and other trans-acting factors control subunit transcription by interacting with CREs, JREs, and upstream response elements in a combinatorial fashion.12, 34, 36, 37, 41 The hCG- genes are also transcriptionally regulated by cAMP, but respond more slowly.42 The cAMP response elements in the hCG- gene promoters are different from those of the hCG- subunit gene