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In patients treated with semaglutide, median duration of nausea was 8 days, vomiting 2 days, diarrhoea 3 days, and constipation 47 days. Over the 68-week trial period nausea occurred in 43.9% of patients (16.1% placebo)

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These effects were generally dose-dependent, most pronounced during dose escalation, and are consistent with the known side effect profile of approved GLP-1 receptor agonists

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