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It enables the cellular movement necessary for wound healing while also being implicated in cancer cell metastasis when the pathway becomes dysregulated
Hu C (2025) Prevention of cardiovascular disease for healthy aging and longevity: a new scoring system and related mechanisms-hallmarks-biomarkers. Ageing Res Rev 107:102727
At the AMY 3 R, the RAMP3/CTR interface for the Cagri-bound AMY 3 R appears to be weaker than the rAmy-AMY 3 R where Y37 rAmy forms a H-bond interaction with E74 RAMP3 that stabilises the position of the ECD and the interface between the RAMP3 and CTR ECDs
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