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The SURPASS-2 trial showing tirzepatide achieving significantly greater HbA1c reduction and weight loss than semaglutide in T2DM patients, and the SURMOUNT trials showing up to 22% average body weight reduction in obese patients, have established tirzepatide as the clinical performance leader in the class
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Furthermore, the combination treatment of liraglutide and metformin was more effective than metformin alone in reducing body weight, waist circumference, and several parameters of insulin resistance [19]
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