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Serious Adverse Events Both medications carry the same class-wide warnings: risk of pancreatitis, gallbladder disease (particularly at higher rates of weight loss), and a theoretical risk of medullary thyroid carcinoma (MTC) based on rodent studies

For the dichotomous variables, we counted the number of cases, using the average RR to estimate the risk ratio.The WMD and RR with 95% CI were calculated for the continuous and dichotomous outcomes respectively, to represent the pooled effects and safety conditions of semaglutide on outcomes of interest

Tirzepatide (Zepbound, 15 mg weekly), SURMOUNT-1, 72 weeks: mean weight loss approximately 22.5%