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What is now needed are larger, prospective, randomized trials that can establish causality, characterize which women benefit most, identify the optimal timing and formulation of each therapy, and track outcomes across the full range of health domains this article has examined, metabolic, cardiovascular, cognitive, and functional

28 Foundational studies of lipid autoxidation chemistry have been essential in establishing this framework and in showing that radical-trapping antioxidants act by terminating the chain-propagation phase of lipid peroxidation, 29,30 thereby defining the kinetic control points that govern ferroptotic escalation