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Tretinoin requires patience most users experience an initial purge phase (46 weeks of worse-looking skin as deeper congestion surfaces), followed by clearer skin starting around weeks 812, with broader anti-aging results visible at 46 months

As a methodological proof-of-concept only, we additionally performed a Bayesian network meta-analysis restricted to body-weight change within a prespecified 1216-weeks window in the largest connected treatment network

you still have to implement lifestyle changes

Lastly, there are a minority of studies focusing on the effects of IF on metabolic health irrespective of weight loss, and more studies are needed to further elucidate whether IF could be beneficial in the absence of weight loss