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By midlife, NAD+ can drop by 50%, exacerbated by inflammation and lifestyle.[14] Factors like poor diet, sedentary behavior, or chronic stress further deplete NAD+ by activating consuming enzymes, creating a vicious cycle
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The Direct Answer Block clarifies what most protocol designers miss: tesofensine's triple reuptake inhibition means every compound affecting dopamine, norepinephrine, or serotonin becomes a potential interaction
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