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For pramlintide, controlled studies showed the gastric half-emptying time lengthening from roughly 112 minutes on placebo to about 169177 minutes at 3060 g doses a delay of roughly an hour

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Animal research has explored its potential effects on: Stomach ulcers Intestinal injuries Gastrointestinal inflammation Esophageal damage Intestinal anastomoses Fistulas Short-bowel syndrome NSAID-related injury Alcohol-related gastric damage Mucosal integrity A major review described successful healing across multiple experimental gastrointestinal models, including intestinal anastomoses and several types of gastrointestinal fistulas in rats