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GLP-1 medications like semaglutide and tirzepatide work differently: they slow gastric emptying so you feel full longer and act on appetite regulation in the brain, which many patients describe as quieting constant thoughts about food

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In clinical trials, nausea was the most commonly reported side effect of Ozempic, affecting around 20 percent of participants

Management includes weight control, physical therapy, anti-inflammatories, and surgical interventions